A red meat-derived glycan promotes inflammation and cancer progression

“We present an unusual mechanism for the well-known association between red meat consumption and carcinoma risk involving the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc). We first evaluate the Neu5Gc content of various foods to show that red meats are particularly rich in orally bioavailable Neu5Gc and then investigate human-like Neu5Gc-deficient mice fed this form of Neu5Gc. When such mice were challenged with anti-Neu5Gc antibodies, they developed evidence of systemic inflammation. Long-term exposure to this combination resulted in a significantly higher incidence of carcinomas (five-fold increase) and an association with Neu5Gc accumulation in the tumors. Similar mechanisms may contribute to the association of red meat consumption with other diseases, such as atherosclerosis and type 2 diabetes, which are also exacerbated by inflammation.”

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Published by

Dev Jacobsen

Musician, author and yogi, developer of Palingenics.

4 thoughts on “A red meat-derived glycan promotes inflammation and cancer progression”

  1. You warned me about reductionism. Carcinogenesis is complex to say the least, and while this is significant support for a way of thinking about your diet, I don’t see it as evidence enough to make a change

    1. Red meat eating requires the cruel treatment and brutal slaughter of higher animals, immense wastage of natural resources and heavy pollution by industrial farming operations. Meat contains adrenalin and other fear poisons from the poor animals’ panicked last moments of life. If one is vegetarian for some time and then encounters red meat cooking, the stench is sickening. No civilized person lives at the cost of the lives of others.

      1. What is so complex? There are any number of compelling reasons for giving up red meat, and no reasons at all for not giving it up. No one can prove that red meat is at all necessary for health—in fact, all the evidence points to the opposite conclusion. I have been a vegetarian since age 16 with no ill effects. So the only possible excuse is a lack of will to control one’s senses, and curb the tongue’s lust for the taste of decaying flesh.

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